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A 2022 SURMOUNT-1 trial, published in The New England Journal of Medicine , tested tirzepatide in adults with obesity and found an average weight loss of up to 22.5%

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Measurable weight loss typically begins within the first month, with more significant changes visible by months 2-3

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People with certain health conditions, including a history of pancreatitis, diabetic retinopathy (vision loss or changes in people with type 2 diabetes), or kidney or gallbladder problems, may require extra monitoring while taking semaglutide to ensure the medication remains safe for them to use